Methylation of Cervical Neoplastic Cells Infected With Human Papillomavirus 16
نویسندگان
چکیده
منابع مشابه
Methylation of Cervical Neoplastic Cells Infected With Human Papillomavirus 16
OBJECTIVE This study was conducted to evaluate the role of methylation of adenylate cyclase activating peptide 1 (ADCYAP1), paired box gene 1 (PAX1), cell adhesion molecule 1 (CADM1), and T-lymphocyte maturation-associated protein (MAL) during carcinogenesis. METHODS We evaluated the methylation of 4 genes by using the cervical carcinoma cell lines (CaSki, SiHa, HeLa, and C33A) and cervical n...
متن کاملIntegration of human papillomavirus type 16 in cervical cancer cells
Cervical cancer remains an important cause of women morbidity and mortality. The progression of cervical pathology correlates with the HPV integration into the host genome. However, the data on the viral integration status in cervical dysplasias are controversial. The aim of the current study was to evaluate the status of HPV integration in two types of cervical pathology - invasive and non inv...
متن کاملConserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia.
DNA methylation contributes to the chromatin conformation that represses transcription of human papillomavirus type16 (HPV-16), which is prevalent in the etiology of cervical carcinoma. In an effort to clarify the role of this phenomenon in the regulation and carcinogenicity of HPV-16, 115 clinical samples were studied to establish the methylation patterns of the 19 CpG dinucleotides within the...
متن کاملDeveloping Michigan Cancer Foundation 7 Cells with Stable Expression of E7 Gene of Human Papillomavirus Type 16
Background: Human papillomavirus (HPV) is responsible for the development of cervical neoplasia. Infection with human papillomavirus type 16 (HPV-16) is a major risk factor for the development of cervical cancer. The virus encodes three oncoproteins (E5, E6 and E7), of which, the E7 oncoprotein is the major protein involved in cell immortalization and transformation o...
متن کاملGenotyping human papillomavirus type 16 isolates from persistently infected promiscuous individuals and cervical neoplasia patients.
Nucleotide sequence variation in the noncoding region of the genome of human papillomavirus type 16 (HPV16) was determined by direct sequencing and single-strand conformation polymorphism analysis of DNA fragments amplified by PCR. Individuals of diverse sexual promiscuity and/or cervicopathology were studied. In a group of 14 healthy, monogamous HPV16-positive females, only two HPV16 sequence ...
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ژورنال
عنوان ژورنال: International Journal of Gynecologic Cancer
سال: 2016
ISSN: 1048-891X,1525-1438
DOI: 10.1097/igc.0000000000000582